Shockwave Therapy Neurology

A new state of the art treatment for Alzheimer’s Disease and mild to moderate dementia.

NEUROLITH® by Storz Medical - Extracorporeal Shockwave Therapy for Neurological applications. More than 850,000 people in the UK are living with Alzheimer’s and dementia and this number is growing fast thanks to an ageing population as well as other factors. It’s believed that 1 in 3 people born now will develop this disease. 

The technology behind the NEUROLITH® is called Transcranial Pulse Stimulation (TPS®). TPS® consists of short acoustic pulses with an ultrasound frequency range that permits a well-focused stimulation of the brain at a depth of up to 8 cm. NEUROLITH® received medical CE in December 2018. 

Just six 30 minute treatments over 2 weeks can improve Alzheimer’s and mild to moderate dementia by 10 points on the CERAD scale. 

shockwave therapy for dementia

Studies show that the NEUROLITH®TPS® not only maintains the cognitive abilities of patients with mild to moderate Alzheimer’s disease, but even improve them significantly.Data also shows that the improvements last for at least 3 months after a course of TPS®treatment. TPS® on average improved cognition by 10 points on the CERAD scale. Patients and close relatives also reported noticeable improvements in memory and verbal communication, which subsequently and indirectly led to an increase in social interaction. Some patients event reported an improved sense of direction that enabled them to do their daily tasks independently and safely finding their way home afterwards.

How does Transcranial Pulse Stimulation (TPS®) treat and improve Alzheimer’s Disease? 

TPS® induces mechanotransduction, stimulating growth factors, primarily VEGF3,4. This not only improves cerebral blood flow, but also promotes the formation of new blood vessels (angiogenesis) and nerve regeneration. In addition is causes the release of nitric oxide (NO)5, which leads to direct vasodilation and improved blood circulation. Transcranial Pulse Stimulation (TPS®) enables targeted stimulation of the cerebral regions.

What are the Biological effects of Transcranial Pulse Stimulation (TPS®)?


·      Mechanotransduction(6)

·      Increase in cell permeability (7)

·      Stimulation of mechanosensitive ion channels (6)

·      Release of nitric oxide (NO)5, which leads to vasodilation, increased metabolic activity and angiogenesis and has an anti-inflammatory effect

·      Stimulation of vascular growth factors (VEGF)(3,4)

·      Stimulation of BDNF8

·      Migration and differentiation of stem cells (4,6) 

TPS® stimulates deep cerebral regions, targeting as deep as 8 cm into the brain tissue. Thanks to the short duration of the TPS® stimulation, heating of the tissue is prevented.

The pulses applied to the treatment area thus develop their maximum clinical effectiveness. TPS® treatment is performed directly through skull, non-invasively. The patient remains awake during the treatment in a comfortable seated position. 

The TPS® treatment has been shown to significantly improve CERAD test performance and to reduce Beck’s depression index in patients with mild to moderate dementia. More than 1500 treatments have been performed using the NEUROLITH® system.

What are the Advantages Transcranial Pulse Stimulation of (TPS®)?

·      30 minutes per session in outpatient clinics 

·      6 treatment sessions over 2 weeks

·      A Painless treatment 

·      No side effects

·      Personalised treatments based on MRI data

·      Adjuvant cognitive training not required

·      Non-invasive 

·      No need to shave the hair 

·      The patient can remain mobile in a comfortable seated position during treatment

BodyTrack® – Treatment documentation in real time

The BodyTrack® live tracking technology in the handpiece enables automatic visualisation of the treated regions. Personalised MRI data allows specific characteristics of the patient’s brain to be taken into account. Every time the handpiece position changes, the visualisation of the target regions in the loaded MRI scans is automatically updated. The energy applied is highlighted in colour for ease of use. The BodyTrack® software is a unique tool for the visualization and control of the TPS® pulses applied and of treatment progress.


What are the advantages of the BodyTrack® software?

·      Personalised MRI data

·      Visualisation of MRI data in 3 planes (axial, coronal, sagittal)

·      Coloured visualisation of the treatment region

·      Real-time visualisation of TPS® pulse distribution

·      Continuous visualisation and documentation of the energy applied and of treatment progress


Storz Medical NEUROLITH® – An innovative, highly effective, non-invasive Alzheimer’s treatment

NEUROLITH® – an innovative system with user friendly design features! The shape of the TPS® handpiece minimizes hand fatigue and allows the clinician to work directly on the patient. The coupling surface adapts easily to any shape of head, making the treatment with focused pulses simple and efficient. The NEUROLITH® software includes patient management with retrievable data and recommended treatment parameters.

Transcranial Pulse Stimulation (TPS®) in Alzheimer’s Disease3D camera with patient and handpiece position detection / Calibration probe and tracking glasses with markers / TPS® handpiece with markers

 What are the advantages of the Storz Medical NEUROLITH®?

·      Focused stimulation of deep cerebral regions

·      Personalised 3D visualisation of patient’s head

·      3D infrared camera system for precise cerebral tracking

·      USB interface for MRI data import

·      Patient database



3 - Yahata, K. et al.: Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury, J Neurosurg Spine, Vol. 25(6), Pages 745–755, 2016

4 - Hatanaka, K. et al.: Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction, Am J Physiol Cell Physiol, Vol. 311(3), C378–C385, 2016

5 - Mariotto, S. et al.: Extracorporeal shock waves: From lithotripsy to anti-inflammatory 

action by NO production, Nitric Oxide, Vol. 12(2), 89–96, 2005

6 - D´Agostino, M. C. et al.: Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction, Int J Surg., Dec. 24(Pt B), 147-153, 2015 

7 - López-Marín, L. M. et al.: Shock wave–induced permeabilization of mammalian cells, Phys Life Rev., 26-27:1-38, 2018 

8- Wang, B. et al.: Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway, Int J Mol Sci., Feb 16;18(2). pii: E433, 2017